ANTIMICROBIAL RESISTANCE SOLUTIONS
WITH DR. JOHN H. REX
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R&D Insight
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Antimicrobial resistance poses a catastrophic threat. If we don’t act now, any one of us could go into hospital in 20 years for minor surgery and die because of an ordinary infection that can’t be treated by antibiotics. And routine operations like hip replacements or organ transplants could be deadly because of the risk of infection.
Dame Sally Davies Tweet
Plazomicin EU marketing application is withdrawn: Near zero market value of newly approved antibacterials
Chemical vs. drugs (Part 2): How do you discriminate? / More on halicin
Non-traditional antibiotics: A pipeline review and an analysis of key development challenges
Draft FDA guidance on anti-infectives for children: It’s (mostly) all about PK and safety
The 37,000-year view: Infections in Eurasia
De-risking vaccine development: Insights spanning decades of experience
Global survey of novel antibiotic reimbursement models / PASTEUR Act introduced to US House
FDA Workshop: Animal Models To Support Antibacterial Development (5 Mar 2020, post-meeting notes)
New pipeline analysis: Cancer projects were funded 17x more than antibacterials during 2011-2020
How hard (and how) to Pull? Net value of Pull via a Transferrable Exclusivity Extension (TEE)
Categories of resistance: MDR, XDR, PDR, UDR, and (new!) DTR
Novel Biology, Novel Utility, & the Illusion of Skill: What to develop? What to reward?
The thoughtless person playing with penicillin treatment is morally responsible for the death of the man who succumbs to infection with the penicillin-resistant organism.
Alexander Fleming Tweet
The bipartisan PASTEUR Act is the strongest bill ever written to strengthen antibiotic development and use. It will fix our market failures, expand the pipeline for next generation antibiotics, and save lives. We can’t sit on our hands as this public health crisis arrives – we have to act now.
U.S. Senator Michael Bennet Tweet